Glutaric Acid Accumulation by a Lysine-requiring Yeast Mutant
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چکیده
منابع مشابه
Homocitric acid accumulation by a lysine-requiring yeast mutant.
The accumulation of fi-carboxy-P-hydroxyadipic acid (homocitric acid) in the culture medium of the lysine-requiring yeast mutant, Ly4, grown on limiting amounts of lysine, has been demonstrated. Identity of the biologically formed acid with synthetic homocitric acid was established by comparison of infrared spectra, RF values from paper chromatograms, optical rotations, and melting points. Radi...
متن کاملHomoaconitic acid accumulation by a lysine-requiring yeast mutant.
Homoaconitic acid, the second intermediate of the proposed pathway for lysine biosynthesis in yeast, is accumulated in the growth medium of a lysine-requiring mutant. This acid has been identified on paper and column chromatography by comparing it with authentic cis-homoaconitic acid. The infrared spectrum of the isolated material was identical with that of synthetic cis-homoaconitic acid. In a...
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Inositol phosphates and the enzymes that interconvert them are key regulators of diverse cellular processes including the transcriptional machinery of arginine synthesis [York (2006) Biochim. Biophys. Acta 1761, 552-559]. Despite considerable interest and debate surrounding the role of Saccharomyces cerevisiae inositol polyphosphate kinase (ScIPK2, ARG82, ARGRIII) and its inositol polyphosphate...
متن کاملAccumulation of tricarboxylic acids related to lysine biosynthesis in a yeast mutant.
Accumulation of tricarboxylic acids related to lysine biosynthesis has been demonstrated in a yeast mutant, Ly,,, which requires lysine as a growth factor in synthetic medium but can substitute a-aminoadipic acid for the nutritional requirement of lysine. Both radioactive and nonradioactive intermediates have been isolated from the growth medium under appropriate conditions and have been identi...
متن کاملBiosynthesis of diaminopimelic acid and lysine in Escherichia coli. 1. The incorporation of C from various organic precursors into the diaminopimelic acid of a lysine-requiring mutant.
Diaminopimelic acid, which is widely distributed in bacteria, is converted into lysine by a specific decarboxylase (Work & Dewey, 1953; Dewey, Hoare & Work, 1954; Antia, Hoare & Work, 1957), and it has been suggested as an immediate precursor of lysine in some bacteria. A mutant of Escherichia coli deficient in the decarboxylase requires lysine for growth and accumulates diaminopimelic acid in ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1962
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)70843-6